Acyclovir vs isoprinosine (immunovir) for suppression of recurrent genital herpes simplex infection.
نویسندگان
چکیده
منابع مشابه
Acyclovir vs isoprinosine (immunovir) for suppression of recurrent genital herpes simplex infection.
OBJECTIVE To compare the efficacy and safety of oral acyclovir (400 mg twice daily) with oral isoprinosine (500 mg twice daily) in the suppression of recurrent genital herpes. DESIGN Double-blind, double-dummy, randomised, controlled, parallel group trial. SETTING 13 centres in UK, Belgium and Germany. SUBJECTS 127 immunocompetent patients with frequently recurring genital herpes. MAIN ...
متن کاملAcyclovir suppression to prevent recurrent genital herpes at delivery.
OBJECTIVE To determine if suppressive acyclovir near term decreased the frequency of clinical recurrences at delivery in women with recurrent genital herpes simplex virus (HSV) infection. METHODS We conducted a prospective, double-blind, randomized trial in 234 women with recurrent genital herpes. Women with genital infection of any frequency were enrolled. Patients received either suppressiv...
متن کاملAcyclovir prophylaxis for herpes simplex virus infection.
ACV is an effective agent for the treatment and prophylaxis of HSV infections in both IC and immunologically normal individuals. The drug is well tolerated in both populations and is not significantly associated with clinical or laboratory toxicities. Because of the great potential benefit and low risk, organ transplant recipients and patients with hematologic malignancies undergoing induction ...
متن کاملValacyclovir and acyclovir for suppression of shedding of herpes simplex virus in the genital tract.
BACKGROUND Valacyclovir exhibits better oral absorption and higher, more prolonged serum concentrations than oral acyclovir. The efficacy of valacyclovir and acyclovir on genital herpes simplex virus (HSV) shedding was assessed in a double-blind, 3-period crossover trial. METHODS Sixty-nine immunocompetent participants with genital HSV-2 received oral valacyclovir, acyclovir, and matching pla...
متن کاملLong-term suppression of severe recurrent genital herpes simplex infections with oral acyclovir: a dose-titration study.
Twenty immunocompetent patients, four females and 16 males, with severe recurrent genital herpes (median number of recurrences the previous year 16, range (8-24] entered an open continuous long-term suppressive treatment with oral acyclovir (ACV) for 12 months. The study included a dose-titration schedule: (ACV, 200 mg x 4/1-3 months, ACV, 400 mg x 2/4-6 months, ACV, 200 mg x 2/7-9 months, and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Sexually Transmitted Infections
سال: 1992
ISSN: 1368-4973
DOI: 10.1136/sti.68.5.312